Diastereoselective synthesis of CF-dihydrobenzofurans by [4+1] annulation of -generated CF--quinone methides and sulfur ylides
An efficient and highly diastereoselective synthesis of CF 3 -dihydrobenzofurans by the reaction of in situ -generated CF 3 - o QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corr...
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Published in | RSC advances Vol. 1; no. 63; pp. 38588 - 38591 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
20.10.2020
|
Online Access | Get full text |
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Summary: | An efficient and highly diastereoselective synthesis of CF
3
-dihydrobenzofurans by the reaction of
in situ
-generated CF
3
-
o
QMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF
3
-
o
QM has been utilized first time for the annulation reaction.
The first [4 + 1] annulation reaction of
in situ
-generated highly electrophilic CF
3
-
ortho
-quinone methides with sulphur ylides has been put forth under mild reaction conditions to access CF
3
-dihydrobenzofurans. |
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Bibliography: | Electronic supplementary information (ESI) available. CCDC For ESI and crystallographic data in CIF or other electronic format see DOI 2023269 10.1039/d0ra08289a |
ISSN: | 2046-2069 |
DOI: | 10.1039/d0ra08289a |