Synthesis of -difluoroalkenes nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed. Various substituted trifluoromethyl alkenes and epoxides were found to be suitable reaction substrates. This reaction enabled C(sp 3 )-C(sp 3 ) bond construction through allylic de...

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Published inOrganic & biomolecular chemistry Vol. 18; no. 19; pp. 3674 - 3678
Main Authors Lu, Xiao-Yu, Jiang, Run-Chuang, Li, Jia-Mei, Liu, Chuang-Chuang, Wang, Qing-Qing, Zhou, Hai-Pin
Format Journal Article
LanguageEnglish
Published 20.05.2020
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Summary:A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed. Various substituted trifluoromethyl alkenes and epoxides were found to be suitable reaction substrates. This reaction enabled C(sp 3 )-C(sp 3 ) bond construction through allylic defluorinative cross-coupling of trifluoromethyl alkenes under mild reaction conditions. This methodology was highly compatible with various sensitive functional groups, providing access to a diverse array of functionalized gem -difluoroalkene-containing alcohol compounds. A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
Bibliography:10.1039/d0ob00535e
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob00535e