I-Catalyzed transformation of -aminobenzamide to -ureidobenzonitrile using isothiocyanates
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o -ureidobenzonitriles using o -aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a...
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Published in | Organic & biomolecular chemistry Vol. 18; no. 14; pp. 2678 - 2684 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
08.04.2020
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Online Access | Get full text |
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Summary: | The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of
o
-ureidobenzonitriles using
o
-aminobenzamides and isothiocyanates
via
intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of
o
-ureidobenzonitriles with excellent yields even in a scalable fashion.
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of
o
-ureidobenzonitriles using
o
-aminobenzamides and isothiocyanates
via
intramolecular rearrangement. |
---|---|
Bibliography: | 1 For ESI and crystallographic data in CIF or other electronic format see DOI H-NMR 13 C-NMR, and HRMS spectra of compounds and crystallographic data. CCDC Electronic supplementary information (ESI) available: General experimental protocols, characterization details 1974299 10.1039/d0ob00118j |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/d0ob00118j |