Photo-triggered self-catalyzed fluoroalkylation/cyclization of unactivated alkenes: synthesis of quinazolinones containing the CFR group
A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides has been developed. This transformation exhibits excellent substrate generality with respect to both the coupling partners. Of note is that this is t...
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Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 23; no. 1; pp. 575 - 581 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Published |
18.01.2021
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Online Access | Get full text |
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Summary: | A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides has been developed. This transformation exhibits excellent substrate generality with respect to both the coupling partners. Of note is that this is the first example describing the C
sp
3
-Br bond homolysis of alkyl bromides
via
a substrate (quinazolinones) induced energy transfer process. Additionally, the mild conditions, tolerance to a wide range of functional groups and operational simplicity make this protocol practical for the synthesis of fluorine-containing ring-fused quinazolinones.
A photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides has been developed. |
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Bibliography: | 10.1039/d0gc03761c Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/d0gc03761c |