Overriding selectivity by template assisted -C-H activation of benzophenones

An orthogonal selectivity for distal meta -C-H activation of benzophenone is acheived by overriding the inherent proximal ortho -selectivity through a template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C-C and C-Si bond formation. A reg...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 53; pp. 7281 - 7284
Main Authors Casali, Emanuele, Kalra, Prakriti, Brochetta, Massimo, Borsari, Tania, Gandini, Andrea, Patra, Tuhin, Zanoni, Giuseppe, Maiti, Debabrata
Format Journal Article
LanguageEnglish
Published 02.07.2020
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Summary:An orthogonal selectivity for distal meta -C-H activation of benzophenone is acheived by overriding the inherent proximal ortho -selectivity through a template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C-C and C-Si bond formation. A regioselective meta -C-H activation strategy for benzophenone was successfully developed by overriding the inherent ketone-directed ortho -selectivity.
Bibliography:Electronic supplementary information (ESI) available. CCDC
1996646
For ESI and crystallographic data in CIF or other electronic format see DOI
10.1039/d0cc03172k
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03172k