Gold nanoclusters for biomedical applications: toward studies
In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties. Among them, ultra-small gold nanoclusters (Au NCs) show promising potential due to their o...
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| Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 8; no. 11; pp. 2216 - 2232 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
18.03.2020
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| Online Access | Get full text |
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| Summary: | In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties. Among them, ultra-small gold nanoclusters (Au NCs) show promising potential due to their optical properties and activatable therapeutic activities under irradiation. Furthermore, due to their hydrodynamic diameter of smaller than 6 nm and unique biophysical properties, they also present intriguing behaviors in biological and physio-pathological environments. In this review, we aim to present the latest research studies published on such nanoparticles in animals. We also propose guidelines to identify the main physico-chemical parameters that govern the behaviour of Au NCs after administration in small animals, notably concerning their renal elimination and their ability to accumulate in tumors. Then, we present recent advances in their use as theranostic agents putting them in parallel with other contrast agents.
In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties. |
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| Bibliography: | Dr Jean-Luc Coll is the Director of Research at INSERM (Institut National de la Santé et de la Recherche Médicale) in France. He is in charge of the team "Cancer Targets and Experimental Therapeutics" in the Institute for Advanced Biosciences in Grenoble. JLC had an initial training in molecular biology (thesis in microbial genetics on E. coli), and then focused on cancer, first as a postdoc at the Burnham Institute (La Jolla USA) and then at the Cancer Research Center of Lyon (CRCL - Centre Léon Bérard). For the last 20 years, he has been working at the interfaces between biology, chemistry, physics and medicine with a clinical (veterinary and human) and industrial (2 Start-up) vision. JLC is focused on the use of near-infrared labeled nanoparticles to target tumors, guide surgery and enhance radiotherapy, phototherapy or innovative therapies. In addition to the developments of nanovectors, he is also deeply involved in the generation of innovative adapted medical devices. Dr Estelle Porret received her Chemistry and Physical Engineering degree, with specialization in nano- and microtechnology, from Graduate School of Chemistry, Biology and Physics (ENSCBP) and a Master's level degree in physical chemistry of materials from Bordeaux University in 2016. She joined Dr Jean-Luc Coll's group at the Institute for Advanced Biosciences the same year to obtain her PhD, focusing on the development of novel gold nanoclusters for cancer diagnosis and therapy. Dr Xavier Le Guevel obtained his PhD in 2006 in Chemistry from the University of Tours (France). Following this, he did some post-doctoral fellowships in physics (Rome, Italy), biophotonics (Dublin, Ireland) and biotechnology (Saarbruecken, Germany) between 2006 and 2010 before starting as an independent researcher at the Nanomedicine Centre Bionand in Malaga (Spain). Since 2016, XLG has been a CNRS researcher at the Institute for Advanced Biosciences in Grenoble (France). His work focuses on the development of new nanomaterials such as metal nanoclusters and optical instruments for medical applications and more specifically for cancer treatment and diagnosis from fundamental research to pre-clinical application. |
| ISSN: | 2050-750X 2050-7518 |
| DOI: | 10.1039/c9tb02767j |