ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug deliveryElectronic supplementary information (ESI) available. See DOI: 10.1039/c9sm00480g

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and...

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Main Authors Zhao, Meihui, Zhang, Yu, Yuan, Shirui, Xu, Xiang, Wu, Ziheng, Wu, Zhenghong, Qi, Xiaole
Format Journal Article
Published 08.05.2019
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Abstract We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells. We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels.
AbstractList We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells. We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels.
Author Yuan, Shirui
Wu, Ziheng
Zhao, Meihui
Zhang, Yu
Wu, Zhenghong
Qi, Xiaole
Xu, Xiang
AuthorAffiliation Key Laboratory of Modern Chinese Medicines
Monash University
China Pharmaceutical University
Parkville campus
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  givenname: Xiaole
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  fullname: Qi, Xiaole
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