ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug deliveryElectronic supplementary information (ESI) available. See DOI: 10.1039/c9sm00480g

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and...

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Bibliographic Details
Main Authors Zhao, Meihui, Zhang, Yu, Yuan, Shirui, Xu, Xiang, Wu, Ziheng, Wu, Zhenghong, Qi, Xiaole
Format Journal Article
Published 08.05.2019
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Summary:We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells. We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels.
Bibliography:10.1039/c9sm00480g
Electronic supplementary information (ESI) available. See DOI
ISSN:1744-683X
1744-6848
DOI:10.1039/c9sm00480g