Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamidesElectronic supplementary information (ESI) available. CCDC: 1881814. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9ob00020h

Quinazolinones have broad applications in the biological, pharmaceutical and material fields. Studies on the synthesis of these compounds are therefore widely conducted. Herein, a novel and highly efficient copper-mediated tandem C(sp 2 )-H amination and annulation of benzamides and amidines for the...

Full description

Saved in:
Bibliographic Details
Main Authors Hu, Fangpeng, Cui, Xinfeng, Ban, Zihui, Lu, Guoqiang, Luo, Nan, Huang, Guosheng
Format Journal Article
LanguageEnglish
Published 27.02.2019
Online AccessGet full text

Cover

More Information
Summary:Quinazolinones have broad applications in the biological, pharmaceutical and material fields. Studies on the synthesis of these compounds are therefore widely conducted. Herein, a novel and highly efficient copper-mediated tandem C(sp 2 )-H amination and annulation of benzamides and amidines for the synthesis of quinazolin-4(1 H )-ones is proposed. This synthetic route can be useful for the construction of quinazolin-4(1 H )-one frameworks. A convenient and operationally simple protocol for the synthesis of quinazolin-4(1 H )-one derivatives has been developed via amination and annulation of amidines and benzamides.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
1881814
10.1039/c9ob00020h
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob00020h