A study of the - isomerization preference of -alkylated peptides containing phosphorus in the side chain and backbone

The current work provides a study on the cis - trans isomerization behaviour of N -alkylated peptides decorated with phosphonate ester groups. A Ugi four-component reaction was chosen for the synthesis of N -alkylated peptides, where almost only the cis isomer was detected when the phosphonate ester...

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Published inNew journal of chemistry Vol. 43; no. 32; pp. 1284 - 12813
Main Authors de la Torre, Alexander F, Ali, Akbar, Concepcion, Odette, Montero-Alejo, Ana L, Muñiz, Francisco M, Jiménez, Claudio A, Belmar, Julio, Velázquez-Libera, José Luis, Hernández-Rodríguez, Erix W, Caballero, Julio
Format Journal Article
Published 12.08.2019
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Summary:The current work provides a study on the cis - trans isomerization behaviour of N -alkylated peptides decorated with phosphonate ester groups. A Ugi four-component reaction was chosen for the synthesis of N -alkylated peptides, where almost only the cis isomer was detected when the phosphonate ester group was incorporated as an amine component in the side chain. However, the phosphonate ester group inserted in the backbone, as an isocyanide component, leads preferably to the trans isomer of this kind of peptides. The diverse behaviour of cis - trans isomerization has been explained via spectroscopic nuclear magnetic resonance analysis and computational calculations. The current work provides a study on the cis - trans isomerization behaviour of N -alkylated peptides decorated with phosphonate ester groups.
Bibliography:10.1039/c9nj02234a
Electronic supplementary information (ESI) available. See DOI
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj02234a