A microfluidic organotypic device for culture of mammalian intestines

• Published in: Analytical methods Vol. 12; no. 3; pp. 297 - 33
• Main Authors: Richardson, Alec, Schwerdtfeger, Luke A, Eaton, Diana, Mclean, Ian, Henry, Charles S, Tobet, Stuart A
• Format: Journal Article
• Published: 23.01.2020

The physiological characteristics of the gastrointestinal (GI) tract are diverse and include rapid rates of epithelial turnover, complex nervous and immune systems, a thick mucus layer, and a large microbial population. Most GI models in vitro rely upon cell lines or organoids and consequently lack...