Polymersome-hydrogel composites with combined quick and long-term antibacterial activitiesElectronic supplementary information (ESI) available: Synthesis and characterization of the monomers and polymers, additional SEM images, standard curve of the concentration of penicillin G, and decomposition tests. See DOI: 10.1039/c8tb01608a
We present an antibacterial polymersome-hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly( -caprolactone)- block -poly(lysine- stat -phenylalanine) [PCL- b -P(Lys- stat -Phe)], exhibiting long-acting intrinsi...
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Main Authors | , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
10.10.2018
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Online Access | Get full text |
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Summary: | We present an antibacterial polymersome-hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly( -caprolactone)-
block
-poly(lysine-
stat
-phenylalanine) [PCL-
b
-P(Lys-
stat
-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In addition, penicillin is encapsulated into the polymersomes, showing quick and enhanced antibacterial activities. Furthermore, a dynamic hydrogel network is prepared based on the Schiff base linkages between the aldehyde groups of dibenzaldehyde-functionalized PEG (DF-PEG) and the amino groups of chitosan. During this process, the penicillin-loaded polymersomes are grafted into the hydrogel networks by Schiff base linkages to afford polymersome-hydrogel composites, which exhibit two-stage antibacterial behavior: (1) penicillin can be released from the hydrogel networks for quick antibacterial function; (2) the polymersomes and the remaining penicillin can be further released for long-term antibacterial effects. Overall, this polymersome-hydrogel composite represents a new type of injectable antibacterial biomaterial for quick and long-acting antibacterial applications.
Intrinsically antibacterial polymersomes loaded with antibiotics were incorporated into hydrogels, exhibiting quick and long-acting antibacterial activity. |
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Bibliography: | Electronic supplementary information (ESI) available: Synthesis and characterization of the monomers and polymers, additional SEM images, standard curve of the concentration of penicillin G, and decomposition tests. See DOI 10.1039/c8tb01608a |
ISSN: | 2050-750X 2050-7518 |
DOI: | 10.1039/c8tb01608a |