Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcoholElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ra00682b
Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol ( 1a-c ). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram...
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Main Authors | , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
06.06.2018
|
Online Access | Get full text |
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Summary: | Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water
via
coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (
1a-c
). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram-negative and Gram-positive pathogens including multidrug-resistant pathogens. The coordination polymer
Ag/1c
with a long PEG chain (PEG1000) was demonstrated to be the most effective antibacterial material, and its minimum inhibition concentrations (MICs) could be as low as 15.2 times for common
Staphylococcus aureus
and 4.8 times for methicillin-resistant
Staphylococcus aureus
over that of silver nitrate. With improved antibacterial performance, easy preparation method, improved stability, sustained releasability, outstanding ductility and low cytotoxicity, the as-prepared coordination polymer hydrogels should find various potential applications such as in clinical burn and wound dressings, biofilms, bioadhesives, and coatings of biomedical materials.
Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water
via
coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (
1a-c
). |
---|---|
Bibliography: | 10.1039/c8ra00682b Electronic supplementary information (ESI) available. See DOI |
ISSN: | 2046-2069 |
DOI: | 10.1039/c8ra00682b |