Palladium-catalyzed oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile: a highly efficient strategy toward 3-amidated quinoxalin-2(1H)-onesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob03061h
A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1 H )-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1 H )-ones. A series of 3-acetamino quinoxalin-2(1 H )-one derivatives were constructed with good to excellent yields. This methodolo...
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| Main Authors | , , , , , |
|---|---|
| Format | Journal Article |
| Published |
23.01.2019
|
| Online Access | Get full text |
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| Summary: | A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1
H
)-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1
H
)-ones. A series of 3-acetamino quinoxalin-2(1
H
)-one derivatives were constructed with good to excellent yields. This methodology provided a practical approach to various 3-acetamino quinoxalin-2(1
H
)-ones from the readily available starting material acetonitrile.
An efficient protocol for the synthesis of 3-amidated quinoxalin-2(1
H
)-ones has been developed
via
a palladium-catalyzed cross-coupling reaction of quinoxalin-2(1
H
)-ones with acetonitrile. |
|---|---|
| Bibliography: | 10.1039/c8ob03061h Electronic supplementary information (ESI) available. See DOI |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/c8ob03061h |