Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki-Miyaura cross-coupling of 3-bromopyridine derivativesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob03048k

A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki-Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpa...

Full description

Saved in:
Bibliographic Details
Main Authors Xia, Wang, Zhang, Zhen-Wei, Li, Yongsu, Jiang, Xiaoding, Liang, Hao, Zhang, Yaqi, Cao, Rihui, Qiu, Liqin
Format Journal Article
LanguageEnglish
Published 27.02.2019
Online AccessGet full text

Cover

More Information
Summary:A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki-Miyaura coupling. The chiral-bridged biphenyl monophosphine ligand L1 was found to be much more effective in the reaction enantioselection than its counterpart binaphthyl monophosphine ligands. A series of chiral heterocyclic biaryls with a pyridyl moiety were prepared in moderate to good yields with up to 92% ee via asymmetric Suzuki-Miyaura coupling.
Bibliography:10.1039/c8ob03048k
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob03048k