Regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindolesElectronic supplementary information (ESI) available: Details of the experimental procedure, data, HPLC and NMR spectra of all compounds. See DOI: 10.1039/c8ob00861b
A highly efficient strategy for the regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H 2 O (1 : 9) without the use of catalysts. This protocol provides an atomically economical, catalyst-free and simple route fo...
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Main Authors | , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
15.05.2018
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Online Access | Get full text |
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Summary: | A highly efficient strategy for the regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H
2
O (1 : 9) without the use of catalysts. This protocol provides an atomically economical, catalyst-free and simple route for the construction of synthetically useful 3-(3-indolyl)-oxindole-3-methanols in high yields. Starting from optically active spiro-epoxyoxindoles a variety of enantiospecific 3-(3-indolyl)-oxindole-3-methanols could be obtained in high yields with complete retention of enantioselectivity.
A highly efficient strategy for the regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H
2
O (1 : 9) without the use of catalysts. |
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Bibliography: | 10.1039/c8ob00861b Electronic supplementary information (ESI) available: Details of the experimental procedure, data, HPLC and NMR spectra of all compounds. See DOI |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c8ob00861b |