A nitroreductase and acidity detecting dual functional ratiometric fluorescent probe for selectively imaging tumor cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/C8OB00670A
Nitroreductase and acidity are common features of a tumor, which is associated with serious disease with a high mortality rate. However, solo detection of nitroreductase or acidic environments may cause false-positive results. Thus, it is very meaningful to develop dual functional probes for detecti...
Saved in:
Main Authors | , , , , , |
---|---|
Format | Journal Article |
Language | English |
Published |
02.05.2018
|
Online Access | Get full text |
Cover
Loading…
Summary: | Nitroreductase and acidity are common features of a tumor, which is associated with serious disease with a high mortality rate. However, solo detection of nitroreductase or acidic environments may cause false-positive results. Thus, it is very meaningful to develop dual functional probes for detecting nitroreductase and acidity, as these could be used for accurate tumor imaging. Here we report on the first dual functional ratiometric fluorescent probe,
NAFP
, for acidity and nitroreductase detection. This probe enables the measurement of the acidic microenvironment and the concentration of nitroreductase at the same time and the same site. The probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment. Furthermore, confocal fluorescence imaging of A549 cells indicates that
NAFP
can detect acidity and expressed nitroreductase in living cells.
A dual functional ratiometric fluorescent probe can obviously distinguish acidity, nitroreductase, and nitroreductase in an acidic environment. Confocal fluorescence imaging of A549 cells indicates the probe can detect acidity and expressed nitroreductase in living cells. |
---|---|
Bibliography: | 10.1039/C8OB00670A Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c8ob00670a |