Direct oxidative C-H alkynylation of N-carbamoyl tetrahydroisoquinolines and dihydroisoquinolinesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob00373d

An efficient oxidative C-H alkynylation of N -carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied N -carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free...

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Main Authors Chen, Lei, Sun, Chuanxi, Feng, Guidong, Cao, Min, Zhao, Shu-lei, Yan, Jun, Wan, Ren-zhong, Liu, Lei
Format Journal Article
Published 18.04.2018
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Summary:An efficient oxidative C-H alkynylation of N -carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied N -carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions. Dihydroisoquinolines were also suitable components for the reaction. The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated. An efficient oxidative C-H alkynylation of N -carbamoyl tetrahydroisoquinolines and dihydroisoquinolines is described.
Bibliography:10.1039/c8ob00373d
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00373d