Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: synthesis of quinolactacide and marinamideElectronic supplementary information (ESI) available: Experimental procedures and copies of the NMR spectra of final products. See DOI: 10.1039/c8ob00260f

A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N -allyl imides as starting materials. The nucleophilic addition of a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yields and has been applied for the preparation...

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Bibliographic Details
Main Authors Simic, Milena, Tasic, Gordana, Jovanovic, Predrag, Petkovic, Milos, Savic, Vladimir
Format Journal Article
LanguageEnglish
Published 21.03.2018
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Summary:A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N -allyl imides as starting materials. The nucleophilic addition of a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yields and has been applied for the preparation of naturally occurring quinolactacide and marinamide. A facile synthetic route toward the preparation of pyrrolizinone derivatives has been developed and applied for the synthesis of quinolactacide/marinamide.
Bibliography:Electronic supplementary information (ESI) available: Experimental procedures and copies of the NMR spectra of final products. See DOI
10.1039/c8ob00260f
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00260f