Preparation and evaluation of a polydopamine-modified capillary silica monolith for capillary electrochromatographyElectronic supplementary information (ESI) available. See DOI: 10.1039/c8nj04912b

• Main Authors: Tang, Yixia, Cui, Xiaoqin, Zhang, Yuefen, Ji, Yibing
• Format: Journal Article
• Language: English
• Published: 02.01.2019
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/c8nj04912b

A novel capillary silica monolith (CSM) with surface modification was prepared for capillary electrochromatography (CEC) by using polydopamine (PDA) as a functional coating. For the preparation of PDA-coated CSM, the ratios of oxidant, reaction time and initial DA concentration were optimized. Under the optimal conditions, PDA-CSM showed excellent separation performance. Acidic and basic small molecules were successfully separated. Furthermore, the potential reactivity of PDA was also investigated. A novel graphene oxide (GO)-modified CSM (GO-PDA-CSM) was prepared by using PDA as a linker and the separation performance was investigated by CEC, which showed good separation efficiency toward alkylbenzenes and ephedrine/pseudoephedrine isomers. Moreover, the GO-PDA-CSM exhibited good repeatability and stability. Compared with CSM and GO-modified CSM without PDA coating, the GO-PDA-CSM significantly improved column separation abilities. The PDA-assisted modification method provided a novel, simple, and versatile method for the functionalization of CSM. A novel capillary silica monolith (CSM) with surface modification was prepared for capillary electrochromatography (CEC) by using polydopamine (PDA) as a functional coating.