Nitro sulfonyl fluorides are a new pharmacophore for the development of antibioticsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8me00011e

The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, suc...

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Main Authors Sadlowski, Corinne, Park, Bora, Araujo Borges, Clarissa, Das, Subhamoy, Lucas Kerr, D, He, Maomao, Han, Hesong, Riley, Lee, Murthy, Niren
Format Journal Article
Published 06.08.2018
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Summary:The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii , and Pseudomonas aeruginosa . The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery.
Bibliography:10.1039/c8me00011e
Electronic supplementary information (ESI) available. See DOI
ISSN:2058-9689
DOI:10.1039/c8me00011e