Synergy between nanomaterials and volatile organic compounds for non-invasive medical evaluationElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cs00317c
This article is an overview of the present and ongoing developments in the field of nanomaterial-based sensors for enabling fast, relatively inexpensive and minimally (or non-) invasive diagnostics of health conditions with follow-up by detecting volatile organic compounds (VOCs) excreted from one o...
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| Main Authors | , , , , |
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| Format | Journal Article |
| Published |
02.07.2018
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| Online Access | Get full text |
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| Summary: | This article is an overview of the present and ongoing developments in the field of nanomaterial-based sensors for enabling fast, relatively inexpensive and minimally (or non-) invasive diagnostics of health conditions with follow-up by detecting volatile organic compounds (VOCs) excreted from one or combination of human body fluids and tissues (
e.g.
, blood, urine, breath, skin). Part of the review provides a didactic examination of the concepts and approaches related to emerging sensing materials and transduction techniques linked with the VOC-based non-invasive medical evaluations. We also present and discuss diverse characteristics of these innovative sensors, such as their mode of operation, sensitivity, selectivity and response time, as well as the major approaches proposed for enhancing their ability as hybrid sensors to afford multidimensional sensing and information-based sensing. The other parts of the review give an updated compilation of the past and currently available VOC-based sensors for disease diagnostics. This compilation summarizes all VOCs identified in relation to sickness and sampling origin that links these data with advanced nanomaterial-based sensing technologies. Both strength and pitfalls are discussed and criticized, particularly from the perspective of the information and communication era. Further ideas regarding improvement of sensors, sensor arrays, sensing devices and the proposed workflow are also included.
This review provides an insight into nanomaterial-based sensors for disease diagnostics
via
the detection of volatile organic compounds (VOCs). |
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| Bibliography: | 10.1039/c8cs00317c Rotem Vishinkin received her Bachelor's (2012) degree in Biochemical Engineering from the Technion - Israel Institute of Technology, Israel. Rotem joined the group of Professor Hossam Haick during her BSc research project on development and characterization of chemical sensors based on field effect transistors of Si nanowires. In August 2014, Rotem obtained her MSc degree in Chemical Engineering and currently continues her direct PhD studies on non-invasive tuberculosis detection based on volatile organic biomarker patterns from skin and breath. Her research interests include development of field effect transistors and gold nanoparticle-based sensors for sensing applications and detection of disease-related volatile biomarkers, especially those emitted from the skin, using mass spectrometry methods and nano-arrays of chemical sensors. Morad K. Nakhleh holds a BSc in Emergency Medicine (2006) and MSc in Medical Sciences (2011). In 2014, he received his PhD in Nanoscience and Nanotechnology, under the supervision of Prof. Hossam Haick, at the Russell Berrie Nanotechnology Institute, Technion-IIT, Haifa, Israel. Currently, Dr Nakhleh is performing his postdoctoral studies at INSERM UMR_S999, Le Plessis Robinson, France. In his current research, Dr Nakhleh focuses on the volatolomics associated with pulmonary arterial hypertension (PAH). His goal is to explore the underlying biological and molecular mechanisms of the disease by profiling the volatolome both on the vascular level and in exhaled breath, searching for early biomarkers associated with the diseases. Hossam Haick is a Full Professor in the Technion - Israel Institute of Technology and head of three major European consortia, has received numerous prestigious Prizes and Awards and was included in several important lists, including the list of the world's 35 leading young scientists published by MIT's Technology Review, the Nominet Trust 100 list (London), which includes the world's 100 most influential inventors and digital developments, and the Los Angeles-based GOOD Magazine's list of the 100 most influential people in the world. His research interests include nanomaterial-based chemical (flexible) sensors, electronic skin, nanoarray devices for screening, diagnosis, and monitoring of disease, breath analysis, volatile biomarkers, and molecular electronic devices. Orna Barash has finished her PhD in the Laboratory for Nanomaterial-based Devices (LNBD) under the supervision of Prof. Hossam Haick in 2010. Her research focus was on "Detection and Characterization of Volatile Organic Compounds Exhaled by In Vitro Lung Cancer Cells". Orna has been working as a Researcher with the LNBD group for 2 years and held responsibilities of research management. Orna has recently joined a spin-off company named NanoScent as the Director of Research. NanoScent uses the core technology developed by prof. Hossam Haick at the Technion for scent detection in various fields. Electronic supplementary information (ESI) available. See DOI Yoav Y. Broza received his PhD in Biotechnology & Food Engineering in 2009 from the Technion - Israel Institute of Technology. He is a senior researcher, head of the biological and analytical team in the Laboratory for Nanomaterial-Based Devices, headed by Prof. Hossam Haick. Yoav served as a researcher and consultant in several biomed and food-tech startups in the field of nano-sensors. Additionally, Yoav holds an external lecturer position in the Technion. His current research interests include volatolomics studies, single cell analysis, identification of disease and infectious-agents' biomarkers through volatile gas analysis by analytical methods and nano-arrays, and the development of novel technologies for gas sampling applications. |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c8cs00317c |