A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activitiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc09456j
We designed and synthesized a simple, but highly effective photosensitizer ( G-Mito-Pc ), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We fur...
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Main Authors | , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
15.01.2019
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Online Access | Get full text |
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Summary: | We designed and synthesized a simple, but highly effective photosensitizer (
G-Mito-Pc
), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of
G-Mito-Pc
compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.
A novel effective dual-targeted photosensitizer based on phthalocyanine can precisely target the mitochondria of EGFR overexpressing cancer cells. |
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Bibliography: | 10.1039/c8cc09456j Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c8cc09456j |