A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activitiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc09456j

We designed and synthesized a simple, but highly effective photosensitizer ( G-Mito-Pc ), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We fur...

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Bibliographic Details
Main Authors Zhao, Xuan, Huang, Yuchao, Yuan, Gankun, Zuo, Ke, Huang, Yafan, Chen, Juanjuan, Li, Jinyu, Xue, Jinping
Format Journal Article
LanguageEnglish
Published 15.01.2019
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Summary:We designed and synthesized a simple, but highly effective photosensitizer ( G-Mito-Pc ), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model. A novel effective dual-targeted photosensitizer based on phthalocyanine can precisely target the mitochondria of EGFR overexpressing cancer cells.
Bibliography:10.1039/c8cc09456j
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09456j