Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kineticsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc05381b

Activatable 19 F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by 19 F MRI. In vivo immune response was successfully imaged using the new nanoprobe....

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Bibliographic Details
Main Authors Akazawa, Kazuki, Sugihara, Fuminori, Minoshima, Masafumi, Mizukami, Shin, Kikuchi, Kazuya
Format Journal Article
LanguageEnglish
Published 16.10.2018
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Summary:Activatable 19 F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by 19 F MRI. In vivo immune response was successfully imaged using the new nanoprobe. Tandemly-repeated peptide design enhanced enzyme accessibility and cleavage efficiency of substrates on the nanoparticle surface, resulting in high MRI signal amplification.
Bibliography:10.1039/c8cc05381b
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05381b