An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localizationElectronic supplementary information (ESI) available: Experimental procedures, chemical details, and additional supporting data including ESI-MS, fluorescence images, western blot analysis, HE staining images etc. See DOI: 10.1039/c8cc03430c

An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiatin...

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Main Authors Li, Shiying, Jiang, Xueyan, Zheng, Rongrong, Zuo, Shengjia, Zhao, Linping, Fan, Guiling, Fan, Jinghao, Liao, Yonghua, Yu, Xiyong, Cheng, Hong
Format Journal Article
LanguageEnglish
Published 12.07.2018
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Summary:An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiating the apoptosis-related biochemical cascades. An azobenzene-based heteromeric prodrug (hNDP) was prepared for tumor targeted chemotherapy by regulating subcellular localization.
Bibliography:10.1039/c8cc03430c
etc.
Electronic supplementary information (ESI) available: Experimental procedures, chemical details, and additional supporting data including ESI-MS, fluorescence images, western blot analysis, HE staining images
See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03430c