Transition-metal-free C-H amidation and chlorination: synthesis of N/N′-mono-substituted imidazopyridin-2-ones from N-pyridyl-N-hydroxylamine intermediatesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc02425a

Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C-H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a bro...

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Main Authors Lee, Katarzyna N, Spiegowski, Dominique N, Lee, Johnny W, Lim, Sanghyun, Zhao, Fuhua, Ngai, Ming-Yu
Format Journal Article
LanguageEnglish
Published 19.06.2018
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Summary:Non-symmetric 1,3-substituted imidazopyridin-2-ones are a common structural scaffold found among many biologically active molecules. Herein we report an efficient, mild, and transition-metal free C-H amidation strategy to access such a pyrido-fused cyclic urea framework in good yields and with a broad functional group tolerance. Transition-metal-free C-H amidation and chlorination for the synthesis of N / N ′-mono-substituted imidazopyridin-2-ones from versatile N -pyridyl- N -hydroxylamine intermediates at room temperature.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/c8cc02425a
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02425a