An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteriaElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc02412j

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Ps...

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Main Authors Di Bonaventura, Ivan, Baeriswyl, Stéphane, Capecchi, Alice, Gan, Bee-Ha, Jin, Xian, Siriwardena, Thissa N, He, Runze, Köhler, Thilo, Pompilio, Arianna, Di Bonaventura, Giovanni, van Delden, Christian, Javor, Sacha, Reymond, Jean-Louis
Format Journal Article
LanguageEnglish
Published 15.05.2018
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Abstract We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa . Exploring chemical space can deliver novel antimicrobials against multidrug resistant bacteria.
AbstractList We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa . Exploring chemical space can deliver novel antimicrobials against multidrug resistant bacteria.
Author Di Bonaventura, Ivan
Pompilio, Arianna
Di Bonaventura, Giovanni
Javor, Sacha
Reymond, Jean-Louis
Siriwardena, Thissa N
Capecchi, Alice
Gan, Bee-Ha
van Delden, Christian
Jin, Xian
Köhler, Thilo
He, Runze
Baeriswyl, Stéphane
AuthorAffiliation Department of Microbiology and Molecular Medicine
University of Bern
Department of Biomedical
Oral and Biotechnological Sciences and Center of Excellence on Aging and Translational Medicine (CeSI-MeT)
University of Geneva
University of Chieti-Pescara
Department of Chemistry and Biochemistry
and Service of Infectious Diseases
Shanghai Space Peptides Pharmaceutical Co. Ltd
G. d'Annunzio
University Hospital of Geneva
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