An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteriaElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc02412j

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Ps...

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Main Authors Di Bonaventura, Ivan, Baeriswyl, Stéphane, Capecchi, Alice, Gan, Bee-Ha, Jin, Xian, Siriwardena, Thissa N, He, Runze, Köhler, Thilo, Pompilio, Arianna, Di Bonaventura, Giovanni, van Delden, Christian, Javor, Sacha, Reymond, Jean-Louis
Format Journal Article
LanguageEnglish
Published 15.05.2018
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Summary:We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa . Exploring chemical space can deliver novel antimicrobials against multidrug resistant bacteria.
Bibliography:10.1039/c8cc02412j
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02412j