Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flowElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc02169d
We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A...
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Main Authors | , , , , , |
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Format | Journal Article |
Published |
29.05.2018
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Online Access | Get full text |
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Summary: | We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.
A convenient organo-photocataytic approach to the radical couplings of boronic acid derivatives is described and applied for APIs synthesis. |
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Bibliography: | 10.1039/c8cc02169d Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c8cc02169d |