Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flowElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc02169d

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A...

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Bibliographic Details
Main Authors Lima, Fabio, Grunenberg, Lars, Rahman, Husaini B. A, Labes, Ricardo, Sedelmeier, Joerg, Ley, Steven V
Format Journal Article
Published 29.05.2018
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Summary:We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput. A convenient organo-photocataytic approach to the radical couplings of boronic acid derivatives is described and applied for APIs synthesis.
Bibliography:10.1039/c8cc02169d
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02169d