An automated repeating batch with catalyst recycle approach to nitro group hydrogenolysisElectronic supplementary information (ESI) available: Experimental details, detailed description of equipment set and operational parameters, additional reaction screening details and data. See DOI: 10.1039/c7re00002b

An automated repeating batch approach has been developed for the rapid screening and scale up of a nitroaromatic to aniline catalytic hydrogenolysis. Advantages of this approach include the ability to scale up in small equipment using readily available powdered catalysts, rapid reaction kinetics due...

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Bibliographic Details
Main Authors Cole, Kevin P, Johnson, Martin D, Laurila, Michael E, Stout, James R
Format Journal Article
LanguageEnglish
Published 06.06.2017
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Summary:An automated repeating batch approach has been developed for the rapid screening and scale up of a nitroaromatic to aniline catalytic hydrogenolysis. Advantages of this approach include the ability to scale up in small equipment using readily available powdered catalysts, rapid reaction kinetics due to high catalyst to substrate ratio, lower overall catalyst use, high throughput from a small reactor, and the ability to refresh the catalyst without manual intervention. An automated repeating batch approach with sequestered catalyst has been applied as a method for nitro group hydrogenolysis.
Bibliography:Electronic supplementary information (ESI) available: Experimental details, detailed description of equipment set and operational parameters, additional reaction screening details and data. See DOI
10.1039/c7re00002b
ISSN:2058-9883
DOI:10.1039/c7re00002b