In situ second-harmonic generation mediated photodynamic therapy by micelles co-encapsulating coordination nanoparticle and photosensitizerElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra07334h
The indirect excitation of a photosensitizer mediated with nonlinear optical mechanism is a strategy for applying tissue penetration enhanced near infrared (NIR) light on photodynamic therapy (PDT). Herein, we introduced a NIR-PDT strategy that employed a nonlinear optical nano-conveyor named AHU-1...
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Main Authors | , , , , , |
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Format | Journal Article |
Language | English |
Published |
09.11.2017
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Online Access | Get full text |
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Summary: | The indirect excitation of a photosensitizer mediated with nonlinear optical mechanism is a strategy for applying tissue penetration enhanced near infrared (NIR) light on photodynamic therapy (PDT). Herein, we introduced a NIR-PDT strategy that employed a nonlinear optical nano-conveyor named AHU-1 bearing strong second-harmonic generation (SHG) properties. AHU-1 could emit exactly half of the incident wavelengths for indirectly exciting the strong absorption soret band of the photosensitizers. Biocompatible micelles (mPEG-PDLLA) were applied to simultaneously encapsulate AHU-1 and photosensitizer, chlorin e6 (Ce6), for increasing their solubility and stability. The size and morphology of cargo loaded micelles were characterized by DLS and TEM. The cytotoxicity studies, live cell imaging and
in situ
photodynamic efficacy were conducted on B16 melanoma cells, and the SHG-mediated PDT effectively eliminated the cancer cells. This study provides a novel strategy for the application of nonlinear optical materials in photodynamic therapy.
NIR-PDT strategy was introduced by employing a nonlinear optical conveyor bearing strong second-harmonic generation (SHG) property. A biocompatible micellic system co-delivered the conveyor and photosensitizer for
in situ
NIR-PDT. |
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Bibliography: | 10.1039/c7ra07334h Electronic supplementary information (ESI) available. See DOI |
ISSN: | 2046-2069 |
DOI: | 10.1039/c7ra07334h |