1H NMR metabolomic signatures related to giant cell tumor of the boneElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra07138h

Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1 H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tiss...

Full description

Saved in:
Bibliographic Details
Main Authors Martínez-López, Francisco Javier, Bañuelos-Hernández, Angel E, Becerra-Martínez, Elvia, Santini-Araujo, Eduardo, Amaya-Zepeda, Ruben A, Pérez-Hernández, Elizabeth, Pérez-Hernández, Nury
Format Journal Article
LanguageEnglish
Published 22.09.2017
Online AccessGet full text

Cover

More Information
Summary:Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the 1 H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications. 1 H NMR metabolomic profiling for giant cell tumor of the bone.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/c7ra07138h
ISSN:2046-2069
DOI:10.1039/c7ra07138h