A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent methodDedicated to Prof. Al Padwa, a scholar and a sportsman who has reached pinnacles in both science and sport, on the occasion of his 80th birthday.Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ra06045a

Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea lin...

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Bibliographic Details
Main Authors Fletcher, M. H, Burns-Lynch, C. E, Knouse, K. W, Abraham, L. T, DeBrosse, C. W, Wuest, W. M
Format Journal Article
LanguageEnglish
Published 07.06.2017
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Summary:Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages. Herein we present a scalable and divergent synthesis of cyclic di-nucleotide analog precursors facilitated by differentiated di-amino sugars and a Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.
Bibliography:Dedicated to Prof. Al Padwa, a scholar and a sportsman who has reached pinnacles in both science and sport, on the occasion of his 80
th
Electronic supplementary information (ESI) available. See DOI
birthday.
10.1039/c7ra06045a
ISSN:2046-2069
DOI:10.1039/c7ra06045a