Highly oxygenated caryophyllene-type and drimane-type sesquiterpenes from Pestalotiopsis adusta, an endophytic fungus of Sinopodophyllum hexandrumElectronic supplementary information (ESI) available. CCDC 1534582 and 1534584. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ra04267a
Four new highly oxidized caryophyllene-type sesquiterpenes ( 1-4 ), one new caryophyllene-type natural product ( 5 ), and two new drimane-type sesquiterpenes ( 6 , 7 ), along with eight known compounds have been isolated from an endophytic fungus Pestalotiopsis adusta . Their structures were elucida...
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Main Authors | , , , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
05.06.2017
|
Online Access | Get full text |
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Summary: | Four new highly oxidized caryophyllene-type sesquiterpenes (
1-4
), one new caryophyllene-type natural product (
5
), and two new drimane-type sesquiterpenes (
6
,
7
), along with eight known compounds have been isolated from an endophytic fungus
Pestalotiopsis adusta
. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data analyses. The absolute configurations for
1
and
5
were determined by single-crystal X-ray crystallographic analysis using Cu Kα radiation. The absolute configuration of
6
was determined by CD spectrum associated with TD-DFT calculation of its benzoylated derivative
6a
. The
in vitro
bioassay revealed that
8
and
9
presented cytotoxicity against cancer cell lines A549, HeLa, and SMMC-7721, in which
8
showed comparable activity (IC
50
= 28.3 μM) to the positive control etoposide (IC
50
= 23.2 μM) against SMMC-7721.
Four new highly oxidized caryophyllene-type sesquiterpenes (
1-4
), and two new drimane-type sesquiterpenes (
6
,
7
), along with nine known compounds have been isolated from an endophytic fungus
Pestalotiopsis adusta
. |
---|---|
Bibliography: | Electronic supplementary information (ESI) available. CCDC For ESI and crystallographic data in CIF or other electronic format see DOI 1534582 1534584 and 10.1039/c7ra04267a |
ISSN: | 2046-2069 |
DOI: | 10.1039/c7ra04267a |