Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonatesElectronic supplementary information (ESI) available: 1H and 13C NMR and HPLC traces of reported products. See DOI: 10.1039/c7ob01478c

Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate. Acyclic nucleoside phosphonat...

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Bibliographic Details
Main Authors Azzouz, Mariam, Soriano, Sébastien, Escudero-Casao, Margarita, Matheu, M. Isabel, Castillón, Sergio, Díaz, Yolanda
Format Journal Article
LanguageEnglish
Published 30.08.2017
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Summary:Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate. Acyclic nucleoside phosphonate were prepared in high yield and up to 92% ee using an enantioselective palladium-catalyzed allylic substitution.
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Electronic supplementary information (ESI) available
C NMR and HPLC traces of reported products. See DOI
10.1039/c7ob01478c
H and
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01478c