Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknGElectronic supplementary information (ESI) available: HRESIMS, 1D and 2D NMR spectra, and detailed experimental section. CCDC 1522355. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7nj00059f

• Main Authors: Chen, Senhua, He, Liqing, Chen, Dongni, Cai, Runlin, Long, Yuhua, Lu, Yongjun, She, Zhigang
• Format: Journal Article
• Language: English
• Published: 30.05.2017
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/c7nj00059f

An unusual alkaloid, talaramide A ( 1 ), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by analysis of NMR spectroscopic data, X-ray diffraction data, and electronic circular dichroism (ECD) spectra. Talaramide A ( 1 ) is the second example of an alkaloid that possesses a unique oxidized tricyclic system. A possible biosynthetic pathway for 1 was proposed. Compound 1 showed promising inhibition of mycobacterial PknG activity with an IC 50 value of 55 μM. An unusual alkaloid, talaramide A ( 1 ), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1).