Copper-catalyzed aerobic benzylic sp3 C-H oxidation mediated synthesis of 2,4,5-trisubstituted imidazoles via a domino multi-component reactionElectronic supplementary information (ESI) available: Experimental details, characterization and copies of spectroscopic data. See DOI: 10.1039/c7gc02484c

An efficient and practical aerobic benzylic sp 3 C-H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A...

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Bibliographic Details
Main Authors Jayram, Janeeka, Jeena, Vineet
Format Journal Article
LanguageEnglish
Published 11.12.2017
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Summary:An efficient and practical aerobic benzylic sp 3 C-H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from α-methylene ketones using this innovative methodology. An efficient and practical aerobic benzylic sp 3 C-H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported.
Bibliography:10.1039/c7gc02484c
Electronic supplementary information (ESI) available: Experimental details, characterization and copies of spectroscopic data. See DOI
ISSN:1463-9262
1463-9270
DOI:10.1039/c7gc02484c