Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shellElectronic supplementary information (ESI) available: Additional experimental data (TEM, fluorescence and 1H DOSY-NMR) as well as synthetic details and full analytical characterisation. See DOI: 10.1039/c7cc08127h
We report the synthesis of ABA′ triblock peptide-polysarcosine-peptide conjugates featuring two complementary phenylalanine-histidine pentapeptide strands A/A′. These sequences encode for antiparallel β-sheet formation into folded conjugates, which promote the self-assembly into polysarcosine-shield...
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Main Authors | , , , , , |
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Format | Journal Article |
Language | English |
Published |
04.01.2018
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Online Access | Get full text |
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Summary: | We report the synthesis of ABA′ triblock peptide-polysarcosine-peptide conjugates featuring two complementary phenylalanine-histidine pentapeptide strands A/A′. These sequences encode for antiparallel β-sheet formation into folded conjugates, which promote the self-assembly into polysarcosine-shielded core-shell nanorods. These do not cause aggregation of serum proteins in human blood plasma underlining an enhanced stability.
ABA′ triblock peptide-polysarcosine-peptide conjugates fold into antiparallel β-sheets, which promotes the self-assembly into polysarcosine-shielded core-shell nanorods with protein repellent properties. |
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Bibliography: | 1 H DOSY-NMR) as well as synthetic details and full analytical characterisation. See DOI 10.1039/c7cc08127h Electronic supplementary information (ESI) available: Additional experimental data (TEM, fluorescence and |
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c7cc08127h |