Platinum(iv) oxaliplatin-peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc04764a

Novel Pt( iv ) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of metallodrugs to target a membrane bound heat shock protein 70 positive (memHSP70+) phenotype in cancer cells. The conjugates exhibit superior cytotoxicity as compared to oxaliplatin alone in Pt res...

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Bibliographic Details
Main Authors McKeon, A. M, Noonan, J, Devocelle, M, Murphy, B. M, Griffith, D. M
Format Journal Article
Published 12.10.2017
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Summary:Novel Pt( iv ) tumour penetrating peptide (TPP) conjugates are reported. They are the first example of metallodrugs to target a membrane bound heat shock protein 70 positive (memHSP70+) phenotype in cancer cells. The conjugates exhibit superior cytotoxicity as compared to oxaliplatin alone in Pt resistant colorectal cancer cells with relatively high memHSP70+ expression. Substitution of TPP in Pt( iv ) peptide conjugates with scrambled peptide (ScP) essentially abolishes the observed cytotoxicity. Novel Pt( iv ) tumour penetrating peptide (TPP) conjugates are reported.
Bibliography:10.1039/c7cc04764a
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc04764a