Lipid radicals cause light-induced retinal degenerationElectronic supplementary information (ESI) available: Experimental details and additional data. See DOI: 10.1039/c7cc03387g

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction,...

Full description

Saved in:
Bibliographic Details
Main Authors Enoki, Masataka, Shinto, Saki, Matsuoka, Yuta, Otsuka, Ayasa, Kaidzu, Sachiko, Tanito, Masaki, Shibata, Takahiro, Uchida, Koji, Ohira, Akihiro, Yamato, Mayumi, Yamada, Ken-ichi
Format Journal Article
LanguageEnglish
Published 03.10.2017
Online AccessGet full text

Cover

More Information
Summary:Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models. We have succeeded in detecting and scavenging lipid radicals in the retina of light induced AMD mice model.
Bibliography:10.1039/c7cc03387g
Electronic supplementary information (ESI) available: Experimental details and additional data. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03387g