Copper-mediated C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agentElectronic supplementary information (ESI) available: Details of experimental procedure, compound characterization data and copies of 1H and 13C NMR spectra. See DOI: 10.1039/c7cc03384b

A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for t...

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Bibliographic Details
Main Authors Qi, Chaorong, Hu, Xiaohan, Jiang, Huanfeng
Format Journal Article
LanguageEnglish
Published 13.07.2017
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Summary:A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles. A copper-mediated direct C-H cyanation reaction of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been developed.
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Electronic supplementary information (ESI) available: Details of experimental procedure, compound characterization data and copies of
10.1039/c7cc03384b
H and
C NMR spectra. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03384b