Ionic liquids with thioether motifs as synthetic cationic lipids for gene deliveryElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc03235h

This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C 12 and C 14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click c...

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Bibliographic Details
Main Authors Gaitor, Jamie C, Paul, Lauren M, Reardon, Melissa M, Hmissa, Taha, Minkowicz, Samuel, Regner, Matthew, Sheng, Yinghong, Michael, Scott F, Isern, Sharon, Mirjafari, Arsalan
Format Journal Article
LanguageEnglish
Published 20.07.2017
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Summary:This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C 12 and C 14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity. Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol-yne click chemistry.
Bibliography:10.1039/c7cc03235h
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03235h