An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2Electronic supplementary information (ESI) available: The syntheses and characterization of TPE-Zn2BDPA, toxicity, cell apoptosis detection of Hep-G2 cell line. See DOI: 10.1039/c6tb01734g
A bioprobe, TPE-Zn 2 BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H 2 O 2 . TPE-Zn 2 BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both...
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| Main Authors | , , , , , , |
|---|---|
| Format | Journal Article |
| Published |
17.08.2016
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| Online Access | Get full text |
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| Abstract | A bioprobe, TPE-Zn
2
BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H
2
O
2
. TPE-Zn
2
BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.
A bioprobe, TPE-Zn
2
BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H
2
O
2
. |
|---|---|
| AbstractList | A bioprobe, TPE-Zn
2
BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H
2
O
2
. TPE-Zn
2
BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.
A bioprobe, TPE-Zn
2
BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H
2
O
2
. |
| Author | Lam, Jacky W. Y Leung, Anakin C. S Deng, Haiqin Kwok, Ryan T. K Zhao, Engui Leung, Chris W. T Tang, Ben Zhong |
| AuthorAffiliation | Department of Chemistry The Hong Kong University of Science & Technology (HKUST) HKUST-Shenzhen Research Institute Institute of Molecular Functional Materials Division of Life Science and State Key Laboratory of Molecular Neuroscience South China University of Technology (SCUT) Institute for Advanced Study Division of Biomedical Engineering SCUT-HKUST Joint Research Laboratory Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Guangdong Innovative Research Team State Key Laboratory of Luminescent Materials and Devices |
| AuthorAffiliation_xml | – name: Institute of Molecular Functional Materials – name: Division of Biomedical Engineering – name: SCUT-HKUST Joint Research Laboratory – name: Department of Chemistry – name: Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction – name: Institute for Advanced Study – name: The Hong Kong University of Science & Technology (HKUST) – name: HKUST-Shenzhen Research Institute – name: South China University of Technology (SCUT) – name: Division of Life Science and State Key Laboratory of Molecular Neuroscience – name: Guangdong Innovative Research Team – name: State Key Laboratory of Luminescent Materials and Devices |
| Author_xml | – sequence: 1 givenname: Anakin C. S surname: Leung fullname: Leung, Anakin C. S – sequence: 2 givenname: Engui surname: Zhao fullname: Zhao, Engui – sequence: 3 givenname: Ryan T. K surname: Kwok fullname: Kwok, Ryan T. K – sequence: 4 givenname: Jacky W. Y surname: Lam fullname: Lam, Jacky W. Y – sequence: 5 givenname: Chris W. T surname: Leung fullname: Leung, Chris W. T – sequence: 6 givenname: Haiqin surname: Deng fullname: Deng, Haiqin – sequence: 7 givenname: Ben Zhong surname: Tang fullname: Tang, Ben Zhong |
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| Notes | 2 BDPA, toxicity, cell apoptosis detection of Hep-G2 cell line. See DOI 10.1039/c6tb01734g Electronic supplementary information (ESI) available: The syntheses and characterization of TPE-Zn |
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| Title | An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2Electronic supplementary information (ESI) available: The syntheses and characterization of TPE-Zn2BDPA, toxicity, cell apoptosis detection of Hep-G2 cell line. See DOI: 10.1039/c6tb01734g |
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