Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classesElectronic supplementary information (ESI) available: Notes on mixed halide-triflate heterocycles and details of the Pfizer RKB and CAS Scifinder® searches. See DOI: 10.1039/c6sc02118b

Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactio...

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Bibliographic Details
Main Authors Almond-Thynne, Joshua, Blakemore, David C, Pryde, David C, Spivey, Alan C
Format Journal Article
LanguageEnglish
Published 19.12.2016
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Summary:Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found. Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB and CAS Scifinder® databases, factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends.
Bibliography:10.1039/c6sc02118b
Electronic supplementary information (ESI) available: Notes on mixed halide-triflate heterocycles and details of the Pfizer RKB and CAS Scifinder® searches. See DOI
ISSN:2041-6520
2041-6539
DOI:10.1039/c6sc02118b