Modular sub-monomeric cell-penetrating guanidine-rich peptoids - synthesis, assembly and biological evaluationElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ra27898a

Guanidinium-rich transporters are promising agents to deliver a wide range of molecules through cell membranes. This article reports the synthesis of a modular, conformationally restricted guanidinium display scaffold, designed with the goal to study the impact of conformational restrictions on the...

Full description

Saved in:
Bibliographic Details
Main Authors Marouseau, Etienne, Neckebroeck, Albane, Larkin, Heidi, Le Roux, Antoine, Volkov, Leonid, Lavoie, Christine L, Marsault, Éric
Format Journal Article
LanguageEnglish
Published 18.01.2017
Online AccessGet full text

Cover

More Information
Summary:Guanidinium-rich transporters are promising agents to deliver a wide range of molecules through cell membranes. This article reports the synthesis of a modular, conformationally restricted guanidinium display scaffold, designed with the goal to study the impact of conformational restrictions on the resulting properties of the transporters and ultimately probe the anionic chemical space of the cellular membrane. The scaffold was assembled on solid phase as a peptoid, and its subsequent biological evaluation showed very good cellular penetration and low cytotoxicity. Development of a guanidinium-rich transporters toolset to study GAG-mediated cell permeation.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/c6ra27898a
ISSN:2046-2069
DOI:10.1039/c6ra27898a