Tandem additions of 3,4-dihydroisoquinolines to γ-hydroxy-α,β-unsaturated ketones: a green and new access to oxazolo[2,3-a]tetrahydroisoquinolinesElectronic supplementary information (ESI) available: Experimental procedure, characterization, NMR spectra, single-crystal XRD data. CCDC 1483927-1483929. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ra20708a
Addition reaction of 3,4-dihydroisoquinolines with γ-hydroxy-α,β-unsaturated ketones furnished a variety of diastereomerically pure oxazolo[2,3- a ]tetrahydro-isoquinolines, which could be purified by either recrystallization or solvent evaporation. The reaction proceeded smoothly under "green&...
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| Main Authors | , , , , |
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| Format | Journal Article |
| Published |
26.09.2016
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| Online Access | Get full text |
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| Summary: | Addition reaction of 3,4-dihydroisoquinolines with γ-hydroxy-α,β-unsaturated ketones furnished a variety of diastereomerically pure oxazolo[2,3-
a
]tetrahydro-isoquinolines, which could be purified by either recrystallization or solvent evaporation. The reaction proceeded smoothly under "green" conditions without an additive and catalyst, giving the target molecules in good to excellent yields.
Addition reactions of various 3,4-dihydroisoquinoline derivatives with γ-hydroxy-α,β-unsaturated ketones were carried out in 15 min at room temperature without an additive, providing oxazolo[2,3-
a
]tetrahydroisoquinoline derivatives in high yields. |
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| Bibliography: | For ESI and crystallographic data in CIF or other electronic format see DOI 10.1039/c6ra20708a 1483927-1483929 Electronic supplementary information (ESI) available: Experimental procedure, characterization, NMR spectra, single-crystal XRD data. CCDC |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra20708a |