Cu(i)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridinesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ra02953a

An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2- a ]pyridines ( 3e...

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Main Authors Dheer, Divya, Reddy, K. Ranjith, Rath, Santosh K, Sangwan, P. L, Das, Parthasarthi, Shankar, Ravi
Format Journal Article
LanguageEnglish
Published 18.04.2016
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Summary:An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2- a ]pyridines ( 3e ) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate. An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines, which can serve as active pharmaceutical ingredients (API) of marketed drugs like saripidem and nicopidem.
Bibliography:10.1039/c6ra02953a
Electronic supplementary information (ESI) available. See DOI
ISSN:2046-2069
DOI:10.1039/c6ra02953a