Cu(i)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridinesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ra02953a
An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2- a ]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2- a ]pyridines ( 3e...
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Main Authors | , , , , , |
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Format | Journal Article |
Language | English |
Published |
18.04.2016
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Online Access | Get full text |
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Summary: | An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-
a
]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds
e.g.
2-iodo-imidazo[1,2-
a
]pyridines (
3e
) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using
3e
as an intermediate.
An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-
a
]pyridines, which can serve as active pharmaceutical ingredients (API) of marketed drugs like saripidem and nicopidem. |
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Bibliography: | 10.1039/c6ra02953a Electronic supplementary information (ESI) available. See DOI |
ISSN: | 2046-2069 |
DOI: | 10.1039/c6ra02953a |