Design, synthesis, and characterization of a fluoro substituted novel pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds and their biological applicationsElectronic supplementary information (ESI) available: The spectral data of synthesized compound are shown. See DOI: 10.1039/c6ra01349j

• Main Authors: Karad, Sharad C, Purohit, Vishal B, Avalani, Jemin R, Sapariya, Nirav H, Raval, Dipak K
• Format: Journal Article
• Published: 26.04.2016
• ISSN: 2046-2069
• DOI: 10.1039/c6ra01349j

A novel series of compounds incorporating a fluoro substituted pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds ( 7a-p ) was synthesized in good yields (79-89%). The structures of all the compounds were confirmed using elemental analysis, IR, 1 H NMR, and mass spectral data. The newly synthesized compounds were screened for their preliminary in vitro antibacterial activity against a panel of pathogenic strains of bacteria and fungi; for their antituberculosis activity against Mycobacterium tuberculosis H 37 Rv; and for their and antimalarial activity against Plasmodium falciparum . Compounds 7e , 7o , and 7h were found to possess promising antibacterial potency, while compounds 7c , 7h , and 7j demonstrated better potency against M. tuberculosis H 37 Rv compared with that of rifampicin. Compounds 7b , 7h , 7i , 7l , and 7o were found to possess excellent activity against a P. falciparum strain compared with quinine (IC 50 = 0.826 μM). A novel series of compounds incorporating a fluoro substituted pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds ( 7a-p ) was synthesized in good yields (79-89%).