Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acidsElectronic supplementary information (ESI) available: Synthetic procedures, characterization data and copies of NMR spectra of new compounds. CCDC 1511242. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob02436j

• Main Authors: Kondratov, Ivan S, Logvinenko, Ivan G, Tolmachova, Nataliya A, Morev, Roman N, Kliachyna, Maria A, Clausen, Florian, Daniliuc, Constantin G, Haufe, Günter
• Format: Journal Article
• Language: English
• Published: 18.01.2017

2-Amino-2-(trifluoromethoxy)butanoic acid ( O -trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured p K a and log  D values establish the compound as a promising analogue of natural aliphatic amino acids. The new enantiopure CF 3 O-homoserines might...