Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acidsElectronic supplementary information (ESI) available: Synthetic procedures, characterization data and copies of NMR spectra of new compounds. CCDC 1511242. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob02436j
2-Amino-2-(trifluoromethoxy)butanoic acid ( O -trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured p K a and log D values establish the compound as a promising analogue of natural aliphatic amino acids. The new enantiopure CF 3 O-homoserines might...
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Main Authors | , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
18.01.2017
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Online Access | Get full text |
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Summary: | 2-Amino-2-(trifluoromethoxy)butanoic acid (
O
-trifluoromethyl homoserine) was synthesized as a racemate and in both enantiomeric forms. The measured p
K
a
and log
D
values establish the compound as a promising analogue of natural aliphatic amino acids.
The new enantiopure CF
3
O-homoserines might be promising surrogates of natural α-amino acids. |
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Bibliography: | For ESI and crystallographic data in CIF or other electronic format see DOI 10.1039/c6ob02436j Electronic supplementary information (ESI) available: Synthetic procedures, characterization data and copies of NMR spectra of new compounds. CCDC 1511242 |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c6ob02436j |